Top favourites Manchester United face Russian Premier League side FK Rostov while two national ties are the other highlights with FC Schalke 04 taking on Borussia Mönchengladbach in a west German derby, while KAA Gent host KRC Genk face each other in an all Belgian tie.
The 16 home and away ties would be played with the first leg on March 9 and the return legs on March 16.
UEFA Europa League – Pre-Quarterfinals
Celta Vigo (ESP) vs FC Krasnodar (RUS)
APOEL Nicosia (CYP) vs RSC Anderlecht (BEL)
FC Schalke 04 (GER) vs Borussia Mönchengladbach (GER)
Olympique Lyon (FRA) v AS Roma (ITA)
FK Rostov (RUS) v Manchester United (ENG)
Olympiacos Piräus (GRE) v Besiktas Istanbul (TUR)
KAA Gent (BEL) v KRC Genk (BEL)
FC København (DEN) v Ajax Amsterdam (NED)