Top favourites Manchester United face Belgian record champions RSC Anderlecht while the other top tie is Dutch side Ajax Amsterdam face German Bundesliga side FC Schalke 04.
The four home and away ties would be played with the first leg on April 13 and the return legs on April 20.
UEFA Europa League – Quarterfinals
RSC Anderlecht – Manchester United
Celta de Vigo – KRC Genk
Ajax Amsterdam – FC Schalke 04
Olympique Lyonnais – Besiktas Istanbul