Below is the complete program of the two legs
First Leg
| Date | Time | Match | Venue | City |
|---|---|---|---|---|
| 04.03.2022 | 13h00 | Uganda – Ethiopia | St Mary’s Stadium | Kampala |
| 05.03.2022 | 16h30 | Senegal – Ghana | Stade Lat-Dior | Thies |
| 06.03.2022 | 13h00 | Tanzania – Botswana | Amaan Stadium | Zanzibar City |
| 06.03.2022 | 14h30 | DR Congo – Nigeria | Stade des Martyrs | Kinshasa |
| 06.03.2022 | 16h00 | Liberia – Guinea | TBC | TBC |
| 06.03.2022 | 16h00 | Benin – Morocco | Stade Charles de Gaulle | Porto-Novo |
| 04, 05 or 06.03.2022 | TBC | Eritrea – Cameroon | TBC | TBC |
Second Leg
| Date | Time | Match | Venue | City |
|---|---|---|---|---|
| 19.03.2022 | 14h00 | Cameroon – Eritrea | Stade Ahmadou Ahidjo | Yaounde |
| 19.03.2022 | 15h00 | Nigeria – DR Congo | MKO Abiola Stadium | Abuja |
| 19.03.2022 | 16h00 | Morocco – Benin | Complexe sportif Prince Moulay Al Hassan | Rabat |
| 20.03.2022 | 13h00 | Ethiopia – Uganda | Abebe Bekila Stadium | Addis Ababa |
| 20.03.2022 | 14h00 | Botswana – Tanzania | Obed Itani Chilume Stadium | City of Francistown |
| 20.03.2022 | 15h00 | Ghana – Senegal | Accra Sports Stadium | Accra |
| 20.03.2022 | 16h00 | Guinea – Liberia | Stade du 28 septembre | Conakry |
*Note the withdrawals this time of Namibia, Guinea-Bissau, Djibouti and Sao-Tome, as well as the disqualification of Kenya.