As confirmed on July 5, 2021, all matches will be played as single leg ties with the AFC Champions League 2021 Quarterfinals and Semifinal (West) scheduled to take place in Saudi Arabia from October 16 to 19 before the decisive Final is held on November 23.
The Korea Football Association has already been confirmed as the centralised host Member Association for the East region matches, which will be staged in Jeonju from October 17 to 20.