Esperance faces Al Ahly at Stade Olympique De Rades, Tunis, while Wydad receives Kaizer Chiefs at Complexe Mohamed V Stadium, Casablanca.
This is after receiving an application from the host member and approvals from governmental and health authorities in Tunisia and Morocco.
CAF has stressed that all medical precautions should be followed at all times in respect to CAF Covid-19 health protocols.