Following is Matchday 5 full schedule (Kickoff time in GMT).
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| Date | Time | Group | Venue | Match |
|---|---|---|---|---|
| 11.11.2021 | 13:00 | E | St. Mary’s Stadium – Kitende | Uganda – Kenya |
| 11.11.2021 | 13:00 | G | Orlando Stadium – Johannesburg (South Africa) | Ethiopia – Ghana |
| 11.11.2021 | 13:00 | J | Benjamin Mkapa Stadium – Dar Es Salaam | Tanzania – DR Congo |
| 11.11.2021 | 16:00 | E | Stade Regional Nyamirambu – Kigali | Rwanda – Mali |
| 11.11.2021 | 16:00 | H | Stade Alphonse Masama Debat – Brazzaville | Congo – Namibia |
| 11.11.2021 | 16:00 | J | Stade de l’Amitie – Cotonou | Benin – Madagascar |
| 11.11.2021 | 19:00 | G | FNB Stadium – Johannesburg | South Africa – Zimbabwe |
| 11.11.2021 | 19:00 | H | Stade de Kegue – Lome | Togo – Senegal |
| Date | Time | Group | Venue | Match |
|---|---|---|---|---|
| 12.11.2021 | 13:00 | A | Cairo Stadium – Cairo (Egypt) | Djibouti – Algeria |
| 12.11.2021 | 13:00 | A | Grand Stadium – Marrakech (Morocco) | Burkina Faso – Niger |
| 12.11.2021 | 16:00 | F | Stade de Franceville – Franceville | Gabon – Libya |
| 12.11.2021 | 16:00 | I | Stade General Lansana Conte – Conakry | Guinea – Guinea Bissau |
| 12.11.2021 | 19:00 | F | 11 November Stadium – Luanda | Angola – Egypt |
| 12.11.2021 | 19:00 | I | Prince Moulay Abdellah Complex – Rabat | Sudan – Morocco |
| Date | Time | Group | Venue | Match |
|---|---|---|---|---|
| 13.11.2021 | 13:00 | B | National Heroes Stadium – Lusaka | Zambia – Mauritania |
| 13.11.2021 | 13:00 | D | Orlando Stadium – Johannesburg (South Africa) | Malawi – Cameroon |
| 13.11.2021 | 16:00 | B | Estadio de Malabo – Malabo | Equatorial Guinea – Tunisia |
| 13.11.2021 | 16:00 | C | Grand Stadium – Tangiers (Morocco) | Liberia – Nigeria |
| 13.11.2021 | 16:00 | C | Stade Municipal Adrerito Sena – Mindelo | Cape Verde – Central African Republic |
| 13.11.2021 | 19:00 | D | Stade de l’Amitie – Cotonou (Benin) | Cote d’Ivoire – Mozambique |