The four home and away ties would be played with the first leg on April 11 and the return legs on April 18.
The top clash of the quarterfinals is between Italian Serie A side SSC Napoli and Arsenal FC of the English Premier League.
UEFA Europa League – Quarterfinals
Arsenal FC (ENG) – SSC Napoli (ITA)
CF Villarreal (ESP) – CF Valencia (ESP)
Benfica SL (POR) – Eintracht Frankfurt (GER)
Slavia Praha (CZE) – FC Chelsea (ENG)