Born in Almere in the Netherlands on November 3, 2002, Dest came through the youth ranks at Ajax Amsterdam and made his first-team debut in 2019. In total, he made 38 appearances for the Dutch side scoring two goals, and winning a Dutch Supercup.
In 2020, he joined FC Barcelona notching up 72 appearances and scoring two goals; he also won a Spanish Cup.
As per the national team, he has 17 appearances and 3 goals for the USA, winning the CONCACAF Nations League 2019/20.